Magnesium Sulfate; Postoperative Nausea and Vomiting; Laparoscopic Surgery

• Status: Unknown status
• Trial end date: 2019-05-30
• Target enrollment: 0
• Participant gender: Female

Summary

Postoperative nausea and vomiting (PONV) is commonly accompanied in patients undergoing surgery under general anesthesia. The patients undergoing laparoscopic gynecologic surgery have multiple risk factors for developing PONV such as female gender, nonsmoker, postoperative opioids, and laparoscopic surgery. Thus, it is important to prevent PONV in these patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gangnam Severance Hospital
• Treatments: Anesthetics; Magnesium Sulfate

Criteria

Inclusion Criteria:

• Gynecologic disease

• Female patients undergoing laparoscopic gynecologic surgery and receiving postoperative fentanyl based intravenous patient controlled analgesia (PCA), aged 20-65 years.

Exclusion Criteria:

• impaired renal or hepatic function (Glutamic Oxalacetate Transaminase [GOT]/Glutamic Pyruvate Transaminase [GPT]>50, estimated glomerular filtration rate [eGFR]<60)

• atrioventricular block, myopathies, diabetes, treated with calcium channel blockers

• History of receiving antiemetics within 1 day before surgery

• History of receiving opioids or non-steroidal anti-inflammatory drugs within 1 week of surgery

• drugs or alcohol abuse

• patients treated with isoniazid, chlorpromazine, or digoxin

• patients who cannot communicated with others or with cognitive dysfunction

• patients who cannot read informed consent