Magnesium Sulfate as Adjuvant Analgesia and Its Effect on Opiate Use of Post-operative Transplant Patients in the Pediatric ICU

• Status: Recruiting
• Trial end date: 2023-08-01
• Target enrollment: 0
• Participant gender: All

Summary

To use magnesium sulfate as adjuvant analgesia by implementing a treatment protocol in order to determine whether can benefit pediatric pain in post-operative transplanted patients and decrease overall opioid consumption.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Minnesota
• Treatments: Magnesium Sulfate

Criteria

Inclusion Criteria:

Experimental Group:

• Be scheduled for and receive a liver transplant or total pancreatectomy and islet cell autotransplantation

Control Group:

• Received a liver transplant or total pancreatectomy and islet cell autotransplantation.

Exclusion Criteria:

Experimental Group:

• Pregnant or unwilling to abstain from sex if not practicing birth control during participation in the study.

• Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.

• Known allergic reactions to components of the MgSO4

• History of heart block or myasthenia graves in past medical history.

• Presence of cardiac pacemaker

• Any patient with preoperative creatinine level > 1.5x upper limit of normal.

Control Group:

• Any patient who had filed as research-exempt (opt-out of research previously).

• Any patient with preoperative creatinine level > 1.5x upper limit of normal.