Magnesium Sulfate as an Adjuvant to Propofol During Consious Sedation in Colonoscopy
Status:
Not yet recruiting
Trial end date:
2025-12-01
Target enrollment:
Participant gender:
Summary
Colonoscopy is one of the most commonly performed outpatient procedures throughout the world
as a screening, diagnostic, and therapeutic tool to evaluate the large intestine from the
distal rectum to the cecum.Propofol is the most commonly used hypnotic agent in sedation
during endoscopic procedures for its advantages of fast onset and quick recovery. However,
propofol may cause respiratory depression and cardiovascular events, which are easier to
appear in cases of old age and high speed administration of propofol.Magnesium is a
non-specific calcium channel inhibitor and a non-competitive
N-methyl-D-aspartate(NMDA)receptor antagonist, which has analgesic and mild sedative
properties .