Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery

• Status: Completed
• Trial end date: 2019-10-12
• Target enrollment: 0
• Participant gender: All

Summary

MgSO4 was found to reduce the perioperative anesthetic and analgesic requirements when used as an adjuvant to general anesthesia. Fentanyl is a potent opioid and used as adjuvant to other sedatives in awake craniotomy procedure. No study, to the best of our knowledge had evaluated fentanyl continuous infusion, nor MgSo4 infusion as adjuvant sedative agents to propofol during Burr-hole surgery. The aim of this study is to evaluate and compare MgSO4 versus fentanyl continuous infusions for conscious sedation in patients undergoing burr hole surgery for evacuation of subdural hematoma with local infiltration.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kasr El Aini Hospital
• Treatments: Fentanyl; Magnesium Sulfate; Propofol

Criteria

Inclusion Criteria:

• patients with unilateral, chronic subdural hematoma,

• aged above 50 years,

• american society of anesthesiologist-physical status (ASA-PS) grade I-II,

• Glasgow coma scale of 14-15.

Exclusion Criteria:

• Patients with hypertension (Systolic blood pressure > 160 mmHg),

• bradycardia (<50 bpm),

• ischemic heart disease,

• second- or third-degree heart block,

• long-term abuse of or addiction to opioids, and sedative-hypnotic drugs (>6 months),

• allergy to study drugs

• neuropsychiatric diseases

• patients with predicted difficult airway

• patients with history of obstructive sleep apnea

• patients with deviation in the surgical technique

• inadequacy of local anesthesia