Magnesium Sulphate and Rocuronium in Patients Over 60

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effects of MgSO4 administration on the pharmacodynamics of rocuronium in patients with 60 or more years of age.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pedro Rotava
• Collaborator: Instituto Nacional de Cancer, Brazil
• Treatments: Magnesium Sulfate; Rocuronium

Criteria

Inclusion Criteria:

• 60 years or older

• ASA physical status I-III

• Scheduled for elective oncologic head and neck surgery

Exclusion Criteria:

• Severe renal insufficiency (calculated creatinine clearance < 30 ml/min)

• Pre-operatory serum magnesium values > 2.5 mEq/l

• Patients receiving medications known to affect neuromuscular function (furosemide, aminoglycoside, anticonvulsivants, calcio channel blocker, litium, azatioprine, cyclofosfamide)