Magnetic Resonance Imaging Study of Geriatric Depression

• Status: Completed
• Trial end date: 2008-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mclean Hospital
• Collaborators: National Alliance for Research on Schizophrenia and Depression; Pfizer
• Treatments: Sertraline

Criteria

Inclusion Criteria:

• DSM- IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) diagnostic criteria for major depressive disorder

• Hamilton Depression Scale- 17 item version score of 18 or higher

• Must speak English

• Women must be post-menopausal

Exclusion Criteria:

• A current or pervious psychiatric disorder other than MDD

• A current unstable medical condition

• A pacemaker or metal implant

• History of alcohol or drug dependence or abuse within the past year

• Current prescription of excluded medications

• Use of a drug within the last 30 days that was not approved for use by governmental authorities.

• If you or a family member works at McLean Hospital