Maintaining Abstinence in Chronic Cigarette Smokers - 1

• Status: Completed
• Trial end date: 2009-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the extended pharmacological and psychological treatment for chronic cigarette smokers.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Bupropion

Criteria

Subjects (N=400) will be men and women (50%) over the age of 18 who smoke at least 10 cigarettes per day and answers yes to the question "Do you smoke within 30 minutes of arising?"

Inclusion Criteria:

-Subjects are age 18 and over, currently smoking 10 or more cigarettes per day, and report a smoking history of at least 5 years in response to the question "How long have you been a regular smoker?"

Exclusion Criteria:

• History of seizure or head injury resulting in unconsciousness

• Any condition that might predispose to seizures (brain tumor or stroke)

• A current or history of anorexia nervosa or bulimia

• Any disease acutely life-threatening or so severe that the patient is judged unable to comply with the protocol

• Use of a protease inhibitor of MAO inhibitor within the last two week

• Current use of psychiatric drugs that would interfere with interpretation of study results, including antidepressants

• Treatment for alcohol dependence during the last year, or evidence of alcohol abuse so severe that the patient is judged potentially unable to comply with the protocol

• Patients who know they are leaving the Bay Area within the study period and non-English speakers will be excluded

• Suicidal or homicidal ideation

• Current major depression

• History of bipolar disorder

• Recent (within twelve months) myocardial infarction

• Any other medical condition that would contraindicate use of NRT or bupropion

• Physical limitation so severe that participation in a program of moderate exercise is not possible

• Pregnancy or lactation