Overview
Maintenance Intermittent Therapy for Symptomatic GERD Patients
Status:
Completed
Completed
Trial end date:
2008-06-01
2008-06-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this study to determine the efficacy of 20 mg of rabeprazole given as a maintenance intermittent therapy following acute treatment for Symptomatic Gastroesophageal Reflux Disease (s-GERD).Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Eisai Inc.Treatments:
Rabeprazole
Criteria
Key Inclusion Criteria:1. Male or female patients, 18 to 65 years of age.
2. If female, not of childbearing potential by reason of surgery, radiation or menopause,
or of childbearing potential, but using an approved method of contraception since the
last menstrual period, for example, intrauterine device (IUD), implant, double barrier
method, or oral contraceptives for at least one cycle. Females of childbearing
potential must have a negative urine pregnancy test before medication is dispensed.
3. Patients must report a minimum three-month history of GERD symptoms. GERD symptoms are
defined as heartburn with or without regurgitation or other associated GERD symptoms.
4. Patients must have at least 4 days with heartburn per week in each of the 2 weeks
prior to Screening.
5. Patients must have no esophagitis, with no proton pump inhibitors (PPIs, prescription
or OTC), H2 blockers (prescription or OTC) or prokinetics within 14 days, prior to the
endoscopy.
Key Exclusion Criteria:
1. Evidence of significant hepatic, renal, respiratory, endocrine, hematologic,
neurologic, psychiatric or cardiovascular system abnormalities, unless the Sponsor and
Investigator agree that the nature and severity of any abnormality is unlikely to
interfere with the conduct of the study, the interpretation of study results, or the
health of the patient during the study.
2. Females must not be pregnant, lactating or have a positive urine eta human chorionic
gonadotropin (B-hCG) laboratory result.
3. Patients with a history of allergy or sensitivity to proton pump inhibitors or to
their inactive ingredients.
4. Patients with known gastric ulcer, duodenal ulcer, infectious or inflammatory
conditions of the small or large intestine, malabsorption syndromes, obstruction, a
history of gastrointestinal malignancy, or prior gastric or intestinal surgery
(including vagotomy).
5. Patients who have a history of Barrett's esophagus, esophageal stricture, or pyloric
stenosis.
6. Patients with a history of endoscopically-proven esophagitis any time in the past.
7. Patients who have taken proton pump inhibitors (PPIs, prescription or OTC), H2
blockers (prescription or OTC) or prokinetics within 14 days, prior to Screening
endoscopy, or any of these medications within 7 days prior to the single-blind placebo
run-in period.