Malaria Active Epidemiology and Treatment Study

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

An observational cohort and malaria treatment study in Cambodia.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Armed Forces Research Institute of Medical Sciences, Thailand
• Collaborator: United States Army Medical Materiel Development Activity
• Treatments: Artenimol; Dihydroartemisinin; Piperaquine

Criteria

Inclusion Criteria:

1. Otherwise healthy volunteer, 18-65 years of age, eligible for care at an RCAF facility, and at risk for contracting malaria

2. Able to provide informed consent

3. Likely to reside in endemic area for the duration of the study

4. Available for follow-up for anticipated study duration, and agrees to participate for the duration of the study

5. Authorized by local commander to participate in the study if on active duty

Exclusion Criteria:

1. History of allergic reaction or contraindication to DHA or piperaquine

2. Significant acute comorbidity requiring urgent medical intervention

3. Pregnant or lactating female, or a female of childbearing age who does not agree to use a highly effective method of birth control during the study

4. Clinically significant abnormal EKG, including a QTc interval > 500 ms.

5. Judged by the investigator to be otherwise unsuitable for study participation