Malaria Elimination Pilot Study in Military Forces in Cambodia
Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Antimalarial drug resistance has reached critical levels on the Thai-Cambodian border. Many
have begun advocating for concerted malaria elimination efforts in Cambodia. However, there
is currently no consensus on how malaria elimination is to be achieved with the tools
available.
In this study, the investigators will conduct operational research with the Royal Cambodian
Armed Forces (RCAF) and National Malaria Center (CNM) to quantify the relative effectiveness
of the two major interventional approaches - monthly malaria prophylaxis (MMP) or focused
screening and treatment (FSAT) - in a head to-head comparison. In addition, the investigators
will quantify the relative contribution of a recently advocated vector intervention for
military personnel - the insecticide treated uniform (ITU) - in addition to other vector
control measures currently employed by the RCAF. The investigators will employ the same
permethrin insecticide self-application kits currently used by the US military. The
investigators will estimate the cost effectiveness of each approach and attempt to define the
best way forward for malaria elimination efforts in a critically important malaria reservoir
in military population (and their dependents) who reside on the Thai-Cambodian border. The
aim of the study is not only to conduct research to better define the best way forward in
malaria elimination efforts in the high risk military populations, but to also build capacity
within the RCAF to support and lead future elimination efforts in the most difficult-to-reach
mobile populations.
Phase:
Phase 4
Details
Lead Sponsor:
Armed Forces Research Institute of Medical Sciences, Thailand
Collaborators:
Ministry of National Defense, Royal Cambodian Armed Forces Department of Health National Center for Parasitology, Entomology, and Malaria Control (CNM)