Malic Acid in Treatment of Xerostomia

• Status: Recruiting
• Trial end date: 2021-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Background: xerostomia is a subjective sensation of dry mouth resulting from quantitative and /or qualitative changes of saliva. Patients receiving drugs like antihypertensives and antidepressants or patients receiving chemotherapy or radiotherapy for treatment of head and neck cancers may suffer from xerostomia. It also can be experienced in patients with systemic diseases like diabetes mellitus, systemic lupus erythematosus, sjogren's syndrome and rheumatoid arthritis. Malic acid spray with concentration of 1% has grabbed the attention over the last few years as an effective treatment for xerostomia.

Study objective: To evaluate the effect of 1% malic acid spray in treatment of xerostomia in type 2 diabetic patients.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hams Hamed Abdelrahman

Criteria

Inclusion Criteria:

• Patients with type 2 diabetes mellitus suffering from xerostomia.

• Patients aged between 35 and 50 years old.

• Glycated hemoglobin less than 7% (28) .

• Duration of diabetes mellitus not less than 4 years and not more than 8 years.

Exclusion Criteria:

• Patients receiving any drugs that cause hyposalivation like anti-hypertensive drugs.

• Patients with any systemic disease reported to produce hyposalivation (sjogren's syndrome, hepatitis c, rheumatoid arthritis and lupus erythematosus) (8).

• Patients receiving chemo-therapy and radio-therapy.

• Mouth breathers.