The goal of this clinical research study is to learn the effect of ZD6474 on the amount of
time between placement of an indwelling pleural catheter and the catheter's removal in
patients with malignant pleural effusion.
This study will also look at the effect that ZD6474 has on tumor cells, biological
characteristics of cells in the body, rate of fluid build-up around the lungs, tumor size,
and thickness of blood vessels. The effect that this drug has on quality of life and
shortness of breath will also be examined.