Management Of Pain After Cesarean Trial

• Status: Recruiting
• Trial end date: 2022-10-15
• Target enrollment: 0
• Participant gender: Female

Summary

This is a double blinded randomized controlled trial to test the efficacy of a combination of acetaminophen and ibuprofen administered to patients on schedule compared to ibuprofen alone on the patient's reported pain score on the second post-operative day after Cesarean delivery. The investigators will also record opiate consumption and pain scores throughout the hospitalization of participants, and will survey patients at one and two weeks after surgery regarding opiate consumption and quality of life.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Milton S. Hershey Medical Center
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

• Pregnant women at least 18 years of age

• Planned delivery via C-section

• Pfannenstiel skin incision

• Lower uterine segment transverse hysterotomy

• English speaking

Exclusion Criteria:

• Major intra-operative or post-operative complication such that clinician recommends patient should not receive non-steroidal anti-inflammatory drugs or that patient requires acetaminophen to treat fever (ie suspected endometritis)

• Unplanned surgery (hysterectomy, bowel/bladder repair)

• Allergy or contraindication to study medication

• Non-English speaking

• Inability to provide informed consent

• History of opioid, other illicit substance, or alcohol use disorder either before or during pregnancy

• Severe renal or hepatic impairment