Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy

• Status: Completed
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the efficacy and safety of oral Nimodipine and IV milrinone combination therapy for management of cerebral spasm after aneurysmal subarachnoid hemorrhage.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zagazig University
• Treatments: Milrinone; Nimodipine

Criteria

Inclusion Criteria:

• Adult patients admitted to our surgical ICU

• aged between (18-60) years old

• World Federation of Neurological Surgeons grades 1-3 Grades

Exclusion Criteria:

• Aneurysmal SAH

• SAH with Fisher Grade I and IV,

• World Federation of Neurological Surgeons grade IV & V

• No informed consent,

• peripheral vascular disease

• Cardiac disease (heart block, severe valvular stenosis, cardiomyopathothy , ejection fraction<40%), Renal impairment (serum creatinine ≥ 1.4 mg.L-1), Hemodynamic instability