Management of Pain in Oral Lichen Planus

• Status: Completed
• Trial end date: 2017-05-22
• Target enrollment: 0
• Participant gender: All

Summary

Treating Oral Lichen Planus (OLP) is a big challenge for clinicians. Despite numerous existing remedies, to date no effective cure has been found, which is mainly attributed to the lack of understanding of the pathogenesis of the disease. The investigator's aim was comparing the effectiveness of topical steroids and diode laser in treating OLP patients. Twenty-four patients with OLP were allocated into two groups of twelve patients each. One group was treated with 970 nm diode laser applied twice weekly and the other group was treated with topical steroids applied four times per day. Patients were followed up for two months. Pain was recorded using the visual analog score (VAS) and the clinical signs and symptoms were recorded using the reticular, atrophic, erosive (RAE) sores. Pain and RAE records were taken before treatment, after treatment and after 2 months.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Sherine Adel Nasry
• Treatments: Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• histological diagnosis of OLP on the basis of WHO criteria (Meji and van der Waal 2003).

• presence of painful and atrophic-erosive oral lesions, unresponsive to topical corticosteroid therapy

• ability to complete the present clinical trial.

Exclusion Criteria:

• Presence of histological signs of dysplasia

• use of lichenoid reaction inducing drugs

• Therapy for OLP in the 2 months prior to the study;

• Patients suffering from any disease that may present with features similar to OLP (graft versus host disease or lupus erythematosus)

• Pregnant or lactating females

• Patients with uncontrolled diabetes or hypertension, positive HCV Ab or HBs Ag.

• Smokers