Management of Post-Induction Hypotension in Emergency Abdominal Surgery
Status:
TERMINATED
Trial end date:
2025-05-06
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to compare the efficacy of two vasopressors (norepinephrine vs. ephedrine) in treating hypotension in adult patients (aged 18+, ASA I-III) undergoing general anesthesia for abdominal surgical emergencies (e.g., appendicitis, intestinal obstruction, peritonitis). The main questions it aims to answer are:
* Which drug is more effective at maintaining intraoperative blood pressure (SBP 80% of baseline)?
* How many boluses of each vasopressor are required to maintain target blood pressure?
Researchers will compare the norepinephrine group (receiving 10 g boluses) to the ephedrine group (receiving 6 mg boluses) to see if norepinephrine is superior for maintaining hemodynamic stability and reduces the number of interventions needed.
Participants will:
* Be randomly assigned to receive one of the two study drugs.
* Undergo standard general anesthesia with close hemodynamic monitoring.
* Receive boluses of the assigned vasopressor whenever their blood pressure drops below a predefined threshold.