Managing Opioid Related Sleep Apnea With Acetazolamide
Status:
Recruiting
Trial end date:
2025-06-01
Target enrollment:
Participant gender:
Summary
Patients with chronic pain who use opioids appear to be at increased risk for breathing
issues during sleep, termed sleep disordered breathing (SDB). Treatment of SDB often consists
of use of a device during sleep that provides continuous positive airway pressure (CPAP) via
a mask interface. However, this device is not effective or tolerated in all individuals. The
goal of this study is to examine whether a medication called acetazolamide can improve SDB,
as an alternative to CPAP treatment.
The investigators will measure the improvement in SDB, as well as any change in symptoms,
during a 1 week treatment with acetazolamide compared with 1 week of placebo (sugar pill).
This study will help to provide data for longer term studies of treatment for SDB in patients
who use opioids.