Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure

• Status: Completed
• Trial end date: 2005-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether mannitol is as effective as hypertonic saline solution in the treatment of elevated intracranial pressure in patients with brain injury.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Grenoble
• Treatments: Mannitol; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• age 18 or older

• sustained elevated intracranial pressure to more than 20 mmHg for more than 10 min

• mechanically ventilated in stable conditions for more than 2 hours prior to the study

• serum osmolality ranged between 280 and 320 mOsm/kg

Exclusion Criteria:

• imminent cranial or extracranial surgery

• leakage or drainage of cerebral spinal fluid

• unstable respiratory and hemodynamic conditions

• oliguric renal failure

• anemia

• use of mannitol or HSS in the previous 6 hours

• concomitant use of thiopentone