Marijuana Drug Discrimination and Self-Administration

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed to investigate the associations among marijuana's discriminative stimulus, reinforcing, subjective (e.g. craving) and physiological effects, and to assess the relative ability of oral THC to block these effects.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wayne State University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Amphetamine; Dextroamphetamine; Dronabinol

Criteria

Inclusion Criteria:

• Female and male volunteers must be in generally good health (as indicated by results from medical history, physical exam, electrocardiogram, urine and blood samples at screening and upon arrival at the laboratory (urine samples only).

• Psychiatric examination must meet DSM-IV criteria for Cannabis Dependence.

• Individuals must be legally and mentally competent to provide written informed consent.

• Those who are unable to give their voluntary informed consent will not be accepted.

Exclusion Criteria:

• Current serious Axis I disorder (except Cannabis or Nicotine Dependence), neurologic, cardiovascular, pulmonary or systemic (e.g., renal, hepatic) disease; cognitive impairment; pregnancy (urine test), lactation (self-report), or not using (self-report) medically approved contraceptives.

• Applicants who express interest in treatment will not be accepted for study and will be provided with a treatment referral.