Main Study Up to 100 subjects, both non-CF volunteers and Cystic Fibrosis (CF) patients, will
participate in a single study visit that will include a DEXA scan, micro CT, and blood
collection.
Denosumab (Prolia) Sub study Approximately 10 adult subjects with CF who participated in the
main study and have results indicating bone disease will receive treatment with Denosumab for
up to 5 years. They will be asked to return annually for repeat DEXA scans, micro CT, and
blood collection.