Mask Ventilation Before and After Neuromuscular Blockade

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Anesthesia providers are taught to "test" that they can properly ventilate a patient's lungs before administering a neuromuscular blocking drug (NMBD), rendering the patient apneic. This is a traditional teaching, not based on empirical evidence. The investigators primary hypothesis is that ventilation after the administration of NMBDs is non-inferior with that before their administration with respect to the composite safety endpoint of inadequate (MVi) and dead-space only (Vds) ventilation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Washington
• Treatments: Bromides; Rocuronium; Succinylcholine; Vecuronium Bromide

Criteria

Inclusion Criteria:

• Patients who are 18 years or greater

• Present for elective surgery and

• Require placement of a breathing tube for their surgery

Exclusion Criteria:

• Patients will not be eligible if they are pregnant

• Are a minor

• Are a prisoner

• Have impaired decision-making capacity

• Have symptomatic untreated reflux

• Prior esophagectomy or hiatal hernia

• Vomiting within 24 hours of surgery

• Known oral or facial pathology making a proper mask fit unlikely

• Any condition for which the primary anesthesia team deems a rapid-sequence intubation to be appropriate

• Prior allergy or contraindication to receiving rocuronium, vecuronium, or succinylcholine.