Maternal Epidural Steroids and Hyperthemia

• Status: Terminated
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to look to see if adding steroids to an epidural reduces the chances of having a fever in labor, and protects the baby from exposure to inflammation.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of South Carolina
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion criteria:

• Nulliparity

• Age>=18

• Patient requests epidural analgesia

• GA >= 37 weeks

Exclusion criteria:

• No prenatal care

• Temperature >99.4 at decision for epidural placement

• Cervical dilation >4cm

• Diabetes (pre-gestational or gestational)

• Autoimmune condition

• Pre-eclampsia

• Maternal heart disease

• Current steroid use

• Active infection (bacterial or viral)

• Wet Tap (CSF on placement of epidural)

• Pre-gestational diabetes

• Known systemic infection (bacterial, viral, fungal or tubercular)

• Known allergy to steroids

• Heart failure

• Hypertensive crisis

• History of active epilepsy