Meal-regulated Substrate Metabolism, Influence of Obesity and IL-6

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The overall purpose of this explorative yet quantitative study project is to understand how blocking IL-6 signaling leads to the expansion of adipose tissue mass in humans in vivo. The aim is to gain in depth knowledge about how IL-6 receptor blockade affects human lipid, glucose and protein metabolism, specifically the uptake and storage of substrates from a meal vs. their utilization, hence the balance determining whether one gains or loses fat mass.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rigshospitalet, Denmark

Criteria

Inclusion Criteria:

Healthy males:

• Age ≥ 18 years and ≤ 40 years

• BMI < 18 and > 25 kg/m2

• Healthy (based on screening)

• Stable body weight for 6 months

Obese males:

• Age ≥ 18 years and ≤ 40 years

• BMI ≥ 30 and ≤ 40 kg/m2

• Healthy (based on screening)

• Stable body weight for 6 months

Exclusion Criteria:

• Smoking

• Evidence of severe thyroid or heart disease, inflammatory diseases, current infection, liver disease (transaminases >2x upper normal range), kidney disease (creatinine >1.5 mg/dl), known immunosuppressive disease, corticosteroid use, regular NSAID or paracetamol usage, aspirin use >100 mg/d, history of carcinoma, history of tuberculosis, anemia (hematocrit <33%), WBC <2 x 10^3/ul, platelets <100 x 10^3/ul, bleeding disorders, obstructive pulmonary disease

• Femoral hernia, vascular prosthesis, vascular thrombosis

• Previous nerve damage, many previous femoral catheter installations