Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding

• Status: Withdrawn
• Trial end date: 2020-04-08
• Target enrollment: 0
• Participant gender: All

Summary

The study aims to describe the changes in Levothyroxine dosage requirements in patients with hypothyroidism started on enteral feeding, and assess whether giving levothyroxine on empty stomach affects the mean percentage increase expected in Levothyroxine dosage in these patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jocelyne Karam
• Collaborator: Maimonides Medical Center

Criteria

Inclusion Criteria:

• Adults admitted to Maimonides Medical Center

• Started on Enteral feeding within 3 days of enrollment: tube feeding, Percutaneous Endoscopic Gastrostomy or PEG tube feeding, or Jejunostomy tube feeding.

• History of Hypothyroidism on a stable dose of Levothyroxine for at least four weeks prior to enteral feeding

• TSH 0.2-10 mIU/ml at enrollment

Exclusion Criteria:

• Concomitant administration of medications that affect thyroid function test including Cholestyramine, Sucralfate, Amiodarone, Lithium, Dopamine, Dobutamine and Dilantin at enrollment.

• Pregnancy

• Known untreated disease or surgery of the small intestine specifically the Jejenum.