Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla

• Status: Completed
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain glucose metabolism in humans. We will measure brain glycogen turnover and content in normal controls and subjects with diabetes under conditions of modest hyper-and hypoglycemia.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Minnesota; University of Minnesota - Clinical and Translational Science Institute
• Treatments: Somatostatin

Criteria

Inclusion Criteria:

• Age 18-65

• Healthy control

• Must be able to provide informed consent

• Type 1 diabetes with hypoglycemia unawareness with hemoglobin A1c < 7.5%

• Poorly controlled diabetics with hemoglobin A1c > 7.5%

• Subjects with hypoglycemia unawareness must report an inability to recognize at least some blood glucose values <58 mg/dL during the 3 months prior to the study.

Exclusion Criteria:

• Over 300 pounds

• Claustrophobic

• History of ischemic heart disease, arrhythmia, of seizure disorder

• Pregnant

• On medications known to alter blood flow or carbohydrate metabolism

• Have internally located pieces of metal