Measurement of Midazolam Levels in Follicular Fluid

• Status: Terminated
• Trial end date: 2019-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics.

The reason to measure Midazolam levels in larger size follicles in this study is to maximize the chances to get a mature oocyte and therefore develop into a potential embryo to be analyzed.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: ART Fertility Clinics LLC; IVI Middle East Fertility Clinic
• Treatments: Midazolam; Propofol

Criteria

Inclusion Criteria:

• Infertility (prim. / sec.)

• Age >18 - ≤ 38 years.

• BMI 19-30

• Stimulation in GnRH-antagonist protocol, using rFSH

• Expected normal ovarian response (6)

• At least 4 follicles with the size ≥ than 17 mm on the day of OPU

• Patients undergoing PGS

• Able to understand the aim of the study and to provide consent

Exclusion Criteria:

• History of endometriosis, classified according to the American Fertility Society (AFS) as stage 3 or more.

• Severe male factor