Measurement of Respiratory Admittance for Pediatric Asthma Diagnosis

• Status: Completed
• Trial end date: 2012-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose is to characterize the change of respiratory admittance induced by salbutamol inhalation in children and young adults. A variation threshold will be fixed to distinguish asthmatic and healthy subjects.

This project could allow a better identification of asthmatic individuals needing a treatment, a reduction of morbidity of asthma, a reduction of unnecessary treatments administered in individuals with respiratory but not asthmatic symptoms, a better comprehension of bronchial hyperreactivity and its role in asthmatic disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Central Hospital, Nancy, France
• Treatments: Albuterol

Criteria

Inclusion Criteria:

Asthmatic children group:

• Several episodes of paroxysmal wheezes, spontaneous or after exercise, without bronchial-pulmonary infection

• Absence of bronchodilator taking during last 12 hours

• Absence of reported intolerance to adrenergic substances

• Parental authorization and consent of child to participate to the study

Control children group:

• Parental authorization and consent of child to participate to the study

Control adult group:

• Consent to participate to the study

Exclusion Criteria:

Control children and adult groups:

• At least 2 episodes of wheezes during breathing

• Several wheezes, abnormal breathlessness, cough during physical exercise

• Asthma diagnosed by family doctor

• Administration of drugs to treat asthma

• Eczema or food allergy at inclusion

• Episode of cough for longer than 6 weeks, without bronchial infection

• Bronchitis, throat infection, rhino-pharyngitis during last 15 days

• Paleness or cyanosis with loss of consciousness when the child was a baby or during an exercise