Measuring Acute Drug Demand in Humans

• Status: Not yet recruiting
• Trial end date: 2029-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Johns Hopkins University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Suvorexant

Criteria

Inclusion Criteria:

• Age between 18 and 65 years old

• Meets Diagnostic and Statistical Manual-5 criteria for Opioid Use Disorder (OUD) (moderate or severe)

• Lifetime substance use history criterion [blinded]

• Medically cleared to take suvorexant and blinded study medications

• Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests

Exclusion Criteria:

• Pregnant or breast feeding

• Seeking opioid use treatment

• Significant mental health or physical disorder that is expected to interfere with study participation as assessed by the study physicians or medical staff

• Known contraindications or allergies to suvorexant and/or the blinded study medications