Measuring Blood Flow in the Brain After Epileptic Activity

• Status: Recruiting
• Trial end date: 2022-10-01
• Target enrollment: 0
• Participant gender: All

Summary

In this clinical trial, postictal phenomena (i.e., headache, delirium) will be investigated after administration of acetaminophen and nimodipine in depressed patients receiving electroconvulsive therapy (ECT). Postictal phenomena are thought to result from decreased cerebral blood flow and decreased oxygen concentration in the brain. It is expected that acetaminophen and nimodipine will reduce these postictal phenomena, compared to no treatment, because they target these mechanisms.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rijnstate Hospital
• Collaborators: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Amsterdam University Medical Center; University of Twente
• Treatments: Acetaminophen; Nimodipine

Criteria

Inclusion Criteria:

• Adulthood (age > 17 years);

• Current clinical diagnosis of depressive episode (unipolar, bipolar, schizoaffective);

• Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements.

Exclusion Criteria:

• Known adverse or allergic reactions to acetaminophen or nimodipine;

• Chronic use of acetaminophen, calcium-antagonists or NSAID's that cannot be interrupted for less than two days before the ECT-session;