Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery

• Status: Recruiting
• Trial end date: 2027-03-01
• Target enrollment: 0
• Participant gender: All

Summary

MOBILE2 is a randomized controlled trial comparing mechanical and oral antibiotic bowel preparation to mechanical bowel preparation only in patients undergoing anterior rectal resection with primary anastomosis. Primary endpoint is Comprehensive Complication Index within 30 days from surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helsinki University Central Hospital
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular

Criteria

Inclusion Criteria:

• Patients scheduled for anterior rectal resection with primary anastomosis

Exclusion Criteria:

• Emergency operation

• Bowel obstruction

• Existing stoma

• Other reason preventing mechanical bowel preparation

• Allergy to neomycin or metronidazole

• Age < 18 years

• Lack of co-operation

Exclusion criteria after randomization:

• Patient did not undergo surgery

• Anterior resection was not performed

• Colonic anastomosis was not performed