Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation
Status:
Not yet recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
It has been shown that prolonged continuous theta burst stimulation (pcTBS) , a relatively
new repetitive transcranial magnetic simulation (rTMS) protocol, of the primary motor cortex
(M1) or dorsolateral prefrontal cortex (DLPFC) decreases pain in healthy volunteers, in
various experimental models. In addition, rTMS of M1 has also been shown to have analgesic
effects in various chronic pain conditions, including neuropathic pain.The mechanisms
underlying rTMS-induced analgesia remain unclear. Functional neuroimaging studies have shown
that rTMS of M1 and DLPFC induces changes in the activity of cortical and subcortical
structures involved in pain processing and modulation. Endogenous opioids and e
N-methyl-D-aspartate (NMDA) receptor are known to play a major role in these processes. The
investigator hypothesized that the endogenous opioids systems (EOS) and NMDA receptor might
be involved in the analgesic action of pcTBS. In the first part,the investigator compares the
analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation
before and after naloxone or placebo treatment, the intensity of pain induced by capsaicin
were used to evaluate the analgesic effects of pcTBS. If naloxone does not reverse the
analgesic effect of pcTBS,The volunteers will be invited to participant the second part of
the study, which the investigator compares the analgesic effects of motor cortex (M1) or
dorsolateral prefrontal cortex (DLPFC) stimulation before and after Ketamine treatment.
Phase:
N/A
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University