Mechanism of Decreased Iron Absorption in Obesity: Controlling Adiposity-related Inflammation

• Status: Completed
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The main iron regulatory protein in the human metabolism is hepcidin. In normal weight, healthy subjects, hepcidin is regulated through the iron status of the body: low iron status results in low hepcidin concentrations, which facilitates dietary iron absorption. In obesity, which is an inflammatory state, hepcidin concentrations are increased and iron absorption is reduced despite low iron stores, leading to iron deficiency over time. Whether lowering the chronic low-grade inflammation during a limited treatment period and thereby lowering hepcidin concentration can improve iron absorption is uncertain.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Swiss Federal Institute of Technology
• Collaborator: University of Monterrey, Mexico
• Treatments: Ibuprofen; Iron

Criteria

Inclusion Criteria:

• normal-weight (BMI18.5-24.9kg/m2) or obesity (BMI 29-40kg/m2)

• pre-menopausal

• no chronic illness and no significant medical conditions that could influence iron or inflammatory status other than obesity

• no-smoking

Exclusion Criteria:

• Diagnosed chronic disease or gastrointestinal disorders

• Metabolic disorders (e.g. diabetes)

• Regular use of medication (except oral contraceptives)

• Subject on a weight loss diet or planning to start a weight loss diet during the duration of the study

• Pregnancy or lactation