Mechanism of Growth Hormone Effects on Adipose Tissue

• Status: Completed
• Trial end date: 2000-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

Growth hormone treatment in humans has been shown to decrease body fat. This study aims to determine what adipose tissue depots are affected by GH and what is the mechanism.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pennington Biomedical Research Center

Criteria

Inclusion Criteria:

• Male, aged 40-70

• Central obesity defined as waist circumference greater than 102 cm and BMI > 27 and < 35 kg/m2

• No weight loss in last 12 months

• Total IGF-1 level < 241 ng/ml (~25th percentile for the assay)

• Body habitus which permitted accurate CT scan acquisition and analysis.

Exclusion Criteria:

• Significant neurologic, metabolic, endocrine, cardiac, respiratory or gastrointestinal disease

• Diabetes

• Known coronary heart disease

• Exercised more than 3 hours per week

• Unwilling or unable to abstain from alcohol for 72 hours prior to the measurements of energy expenditure and fasting blood work