Mechanisms Underlying Metabolic Syndrome in Obesity

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to better understand the link between obesity and diabetes or pre-diabetes.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Philip Kern; University of Arkansas
• Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National Institutes of Health (NIH)
• Treatments: Pioglitazone

Criteria

Inclusion Criteria:

• 18-65 years of age

• BMI 28+

• diabetes, impaired glucose tolerance or normal glucose tolerance

Exclusion Criteria:

• AST >2x normal

• congestive heart failure

• history of coronary artery disease

• chronic renal insufficiency (creatinine > 1.4mg/dl)

• use of gemfibrozil, ACE inhibitors, and angiotensin receptor II blockers, or anticoagulants