Mechanisms for Restoration of Hypoglycemia Awareness
Status:
Recruiting
Trial end date:
2024-06-30
Target enrollment:
Participant gender:
Summary
To assess if using the hypoglycemic clamp and functional magnetic resonance imaging (fMRI)
scanning in hypoglycemia unaware and aware T1DM patients and healthy controls have showed
distinct differences in patterns of brain responses. In particular, T1DM patients who are
aware of hypoglycemia (T1DM-Aware) have greater activity in sensory integration brain regions
(e.g. parietal lobe and caudate nucleus) in response to hypoglycemia, whereas hypoglycemia
unaware T1DM patients (T1DM-Unaware) show no detectable changes in brain reward regions
during hypoglycemia.