Mechanisms of Increased Androgen Production Among Women With Polycystic Ovary Syndrome

• Status: Completed
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

Jeffrey Chang MD is conducting a research study to learn more about the increased male hormone levels, otherwise known as androgens, seen in women with polycystic ovary syndrome (PCOS). Women with PCOS have ovaries that are comprised of many cysts, or follicles. They also have irregular or absent menstrual periods and symptoms of increased male hormones, such as facial hair or acne. In each part of the study (except part 4 which is for PCOS women only) we will be comparing responses of PCOS women to normal controls

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Diego
• Treatments: Adrenocorticotropic Hormone; Androgens; BB 1101; beta-Endorphin; Chorionic Gonadotropin; Cosyntropin; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Follicle Stimulating Hormone; Hormones; Melanocyte-Stimulating Hormones

Criteria

Inclusion Criteria:

A group of 40 women with PCOS and 20 normal women ages 18-37 will be studied.

• Subjects will be determined to have PCOS based on clinical history of irregular menses and clinical or laboratory evidence of hyperandrogenism and polycystic ovaries on ultrasound.

• Subjects should not have been on any hormonal therapy or metformin for at least 2 months prior to study start.

• Subjects will be determined to be normal controls if they have a clinical history of regular periods

Exclusion Criteria:

• Women with hemoglobin less than 11 gm/dl at screening evaluation

• Women with untreated thyroid abnormalities

• Pregnant women or women who are nursing

• Women with BMI > 37

• Women with known sensitivity to the agents being used

• Women with prosthetic devices (i.e.,ear)/ shunts (ventricular), Hearing aids, Metal plate/pins/screws/wires

• Women with diabetes, or renal, liver, or heart disease.