Mechanisms of Insulin Resistance in Humans

• Status: Completed
• Trial end date: 2014-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The Objectives of the study are to: (1)compare the inflammatory response and insulin resistance in skeletal muscles during a systemic infusion of lipid with that during a local infusion of lipid into the femoral artery. which would cause minimal or no systemic hyperlipidemia but local plasma free fatty acid (FFA) concentrations similar to those during the systemic lipid infusion, and (2) determine the inflammatory response and insulin resistance in skeletal muscle during an infusion of lipid into the femoral artery as described above after NF-KB inhibition by high dose salicylate treatment in humans.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: US Department of Veterans Affairs; VA Office of Research and Development
• Treatments: Insulin; Soybean oil, phospholipid emulsion

Criteria

Inclusion Criteria:

• two groups of 16 healthy subjects

Exclusion Criteria:

• diabetes or impaired glucose tolerance

• peripheral vascular disease

• pulmonary disease

• clinically significant hepatic or renal disease

• triglycerides >200mg/dl

• anemia

• abnormal PT, PTT or INR

• pregnancy or lactation