Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome
Status:
Withdrawn
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
Sirtuin activators may prove useful in treating age-related diseases and extending lifespan
in humans. Resveratrol (RSV), a polyphenol found in red wine, has been shown in vitro to
enhance SIRT1 activity. RSV is associated with some of the beneficial effects of red wine or
the "French Paradox". Recently RSV has been associated with increasing lifespan in mice on a
high calorie diet and improved metabolic profile and activity levels. The effect of this
small molecule in humans is unknown. Preclinical observations suggest that RSV is safe and
has enormous potential in the treatment of obesity and insulin resistance in humans. This
pilot study will examine the effect of RSV on improving the metabolic profile of adults with
insulin resistance. Specifically, this randomized double blind placebo controlled study will
examine the effects of 4 weeks of supplementation with RSV 5.0 grams daily, compared to
placebo control (PC) on the metabolic profile of 36 men and women over the age of 50 with
insulin resistance (IR) consuming a typical western diet consisting of at least 40% calories
from fat.