Mechanistically-based Optimization of UV Radiation Therapy in Psoriasis
Status:
Terminated
Trial end date:
2012-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is 1) to determine whether Imiquimod or Steroid pretreatment
modifies UVB laser light response resulting in increased cell death compared to UVB laser
light alone; 2) to determine if pretreatment of psoriatic lesions with Imiquimod or Steroid
prior to UVB laser light exposure selectively effects various T cell functions; 3) to
determine clinical results from the Imiquimod/Steroid/UVB laser light and correlate those
changes with immuno-histochemical changes in the skin; and 4) to determine if single high
dose lesion limited UVB laser light intervention combined with Imiquimod or Steroid
influences T cell changes