Meclizine Plasma Levels in Responders and Non-responders

• Status: Not yet recruiting
• Trial end date: 2021-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Motion sickness is a debilitating condition that can effect many crew members. Meclizine has long been known as an effective anti motion sickness drug. The response to the drug is variable - some are responders, while others are resistant to the drug. The aim of the present study is to examine whether there is a correlation between meclizine plasma levels and clinical response.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Medical Corps, Israel Defense Force
• Treatments: Meclizine

Criteria

Inclusion Criteria:

• Seasickness questioner (WIKER) score of 7.

• Subjective functioning at 1 meter sea voyage - 5/10 and lower.

• Subjects who were prescribed 25mg of meclizine.

• Subjects who did not take any other drugs 48 prior to their participation in the study.

Exclusion Criteria:

• Known hearing loss or any vestibular impairment

• Vertigo complains

• Any ear infection

• Use of Scopolamine based anti-seasickness drugs.

• Use of meclizine 50mg.