Mediators of Abnormal Reproductive Function in Obesity (MARO)
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
The study is seeking to understand how being overweight and obese makes women less fertile.
The studies the investigators have done so far indicate that there is a hormone or other
substance produced by fat that goes into the blood and reduces reproductive hormones in women
who are overweight and obese. The present study will try to find the most promising
substances by studying small numbers of women and trying to remove the substances that are
causing the problem.
Hypothesis: A circulating factor or factors, either hormonal, inflammatory or metabolic,
causes relative pituitary hypofunction and correction of this reproductive deficit will allow
obese women with infertility who have failed to reduce their body weight to normal to
conceive, and may also prevent the horizontal passage of an adverse metabolic phenotype to
the offspring.
Phase:
Early Phase 1
Details
Lead Sponsor:
University of Colorado, Denver
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)