Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer
Status:
Recruiting
Trial end date:
2023-10-31
Target enrollment:
Participant gender:
Summary
This phase II trial studies the effect of megestrol acetate alone or in combination with
metformin in preventing the progression of uterine pre-cancer (endometrial intraepithelial
neoplasia) to endometrial cancer. Megestrol acetate is a drug used to block estrogen and
suppress the effects of estrogen and androgens. It is the current non-surgical treatment of
endometrial intraepithelial neoplasia. Metformin is a drug that has been found to have
anti-cancer properties. Giving metformin and megestrol acetate together may decrease the
growth of endometrial intraepithelial neoplasia in the uterus better than megestrol alone.