Melatonin Effects on Genital Herpes in Brazilian Women
Status:
Unknown status
Trial end date:
2020-02-01
Target enrollment:
Participant gender:
Summary
Genital herpes is a common and increasingly-common infection worldwide. The annual incidence
in the United States is 1.75 per 1000 inhabitants. The etiologic agent is the herpes type 1
and 2 strains simplex virus. Classical Treatment is with acyclovir which decreases the
duration of the disease and prevents rashes but has no curative effect. Also, studies show
herpes resistance to acyclovir which has stimulating research into new drugs to treat this
condition. Authors suggest melatonin way be a therapeutic agent in herpetic disease due to
its modulatory action in immune and inflammatory responses when administered in adequate
doses. Therefore, the aim of this study is to evaluate the effects of melatonin in the
treatment of genital herpes as well as compare it to acyclovir in a double-blind, prospective
and randomized, investigation. Outcame measures will include clinical evaluation of patients
and laboratory endpoints.