Melatonin Effects on Genital Herpes in Brazilian Women

• Status: Unknown status
• Trial end date: 2020-02-01
• Target enrollment: 0
• Participant gender: Female

Summary

Genital herpes is a common and increasingly-common infection worldwide. The annual incidence in the United States is 1.75 per 1000 inhabitants. The etiologic agent is the herpes type 1 and 2 strains simplex virus. Classical Treatment is with acyclovir which decreases the duration of the disease and prevents rashes but has no curative effect. Also, studies show herpes resistance to acyclovir which has stimulating research into new drugs to treat this condition. Authors suggest melatonin way be a therapeutic agent in herpetic disease due to its modulatory action in immune and inflammatory responses when administered in adequate doses. Therefore, the aim of this study is to evaluate the effects of melatonin in the treatment of genital herpes as well as compare it to acyclovir in a double-blind, prospective and randomized, investigation. Outcame measures will include clinical evaluation of patients and laboratory endpoints.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo General Hospital
• Treatments: Acyclovir; Melatonin

Criteria

Inclusion criteria:

• clinical and laboratory diagnosis of genital herpes

• real time PCR

• serology

Exclusion criteria:

• immunodeficiencies

• pregnant women