Melatonin Study Between Diminished and Normal Responder in IVF

• Status: Unknown status
• Trial end date: 2019-10-31
• Target enrollment: 0
• Participant gender: Female

Summary

Poor sleep quality may lead to increase in oxidative stress and free radicals which in turn may decrease the reproductive function. Many researchers have already proven improvement on reproductive function after antioxidant (melatonin) administration. The investigators wish to study the relationship between unexplained, young poor ovarian responder and oxidative stress.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bundang CHA Hospital
• Treatments: Melatonin

Criteria

Inclusion Criteria:

1. Infertility patients visiting Bundang CHA hospital between the age of 20 to 40.

2. Currently, not being treated for any gynecological or medical diseases.

Exclusion Criteria:

1. Current untreated pelvic pathology (moderate-to-severe endometriosis, submucosal uterine fibroids/polyps assessed by the treating specialist to affect fertility, pelvic inflammatory disease,uterine malformations, and hydrosalpinx.)

2. Currently enrolled in another interventional clinical trial.

3. Concurrent use of other adjuvant therapies (e.g.Chinese herbs, acupuncture).

4. Autoimmune disorders.

5. Undergoing preimplantation genetic diagnosis.

6. Concurrent use of any of the following medications (Fluvoxamine,Cimetidine, Quinolones, Carbamazepine, rifampicin,Zolpidem, zopiclone, and other non-benzodiazepine hypnotic, other CYP1A2 inducers.

7. Genetic disorders regarding galactose intolerance, lactase deficiency, glucose-galactose malabsorption

8. Inability to comply with trial protocol.