Melatonin Supplementation in Postmenopausal Women With H. Pylori-associated Dyspepsia
Status:
Completed
Trial end date:
2018-10-26
Target enrollment:
Participant gender:
Summary
Background: The aim of the study was to assess the role of melatonin in chronic dyspepsia in
this group of women, with consideration of Helicobacter infection. Methods: The study
comprised 152 subjects Including 30 healthy women (group I), 60 women with asymptomatic
H.pylori infection (group II), and 64 women H. pylori infected with chronic dyspepsia(group
III). Endoscopic examination, histological assessment of gastric end duodenal mucosa, urease
breath test(UBT-13C), and serum levels of 17-β-estradiol, follicle stimulating hormone,
melatonin and urinary concentration of 6-sulfatoxymelatonin were determined by
immunoenzymatic method. In group III - 14-day antibacterial treatment was introduced with
pantoprazole, amoxicillin and levofloxacin. Afterward, in 32 women was administered
placebo(group IIIa), and in 32 women (group IIIb) melatonin at a dose 1 m/morning and 3 mg/at
bedtime, for six months.
Phase:
N/A
Details
Lead Sponsor:
Medical University of Lodz Medical Universtity of Lodz