Melatonin Treatment and Inflammation, Oxidative Stress and Autonomic Function in Connection With Surgery

• Status: Unknown status
• Trial end date: 2006-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Gentofte, Copenhagen
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• indikation for laparoscopic cholecystectomy

• women between 18 and 70 years old

Exclusion Criteria:

• men

• acute cholecystectomy

• pancreatitis

• renal insufficient

• well-known liver insufficient

• cardiovascular disease (arrhythmia, well-known ischaemic heart disease)

• drug therapy (digoxin, Ca-antagonist, amiodaron, beta-blocker)

• anticoagulation therapy (marevan and marcoumar)

• praeoperative therapy with opioid, anxiolytica and hypnotica)

• well-known sleep disease

• endocrine disease in drug therapy (diabetes mellitus, thyroid disease)

• daily alcohol consumption (more than 5 drinks)

• bad compliance (language difficulty, mental problems etc.)

• pregnancy and breast-feeding

• lack of written consent