Melatonin for Prevention of Radiation Induced Oral Mucositis

• Status: Completed
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The main aim of this study was to evaluate the effectiveness of melatonin in prevention of radiation induced oral mucositis clinically and biochemically.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hams Hamed Abdelrahman
• Collaborators: Alexandria University; Faculty of Dentistry, Alexandria University
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• Patients who are going to receive radiotherapy as a treatment of head and neck cancer either as postoperative (adjuvant) therapy or definitive therapy.

• Patients whose radiotherapy treatment planned dose is between 60-70 Gy.

• Patients who had received chemotherapy prior to radiotherapy or are going to receive chemotherapy in concomitant to radiotherapy.

Exclusion Criteria:

• Patients under Anticoagulants such as warfarin, heparin, or aspirin.

• Patients under Fluvoxamine (Luvox) and Nifedipine medications.

• Patients whose radiotherapy treatment planned dose is lower than 60 Gy.

• Pregnant and lactating women.

• Patients suffering from any uncontrolled systemic diseases (such as diabetes, cardiovascular, liver disorder, renal dysfunction)

• Patients with findings of any physical or mental abnormality which would interfere with or be affected by the study procedure.