Overview

Melatonin on Coronary Artery Calcification

Status:
Unknown status
Trial end date:
2021-06-01
Target enrollment:
0
Participant gender:
All
Summary
We planned to evaluate the effects of melatonin on progression of coronary artery calcification (CAC) in patients with moderate calcified coronary atherosclerosis.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Chinese PLA General Hospital
Treatments:
Melatonin
Criteria
Inclusion Criteria:

Patients with a documented Agatston scoreā‰„30 and moderate calcified coronary
atherosclerosis (<50% diameter lumen narrowing) were eligible for the study.

Exclusion Criteria:

1. unstable angina pectoris

2. symptomatic chronic heart failure and/or left ventricular ejection fraction (EF) <40%

3. atrial fibrillation or other arrhythmias

4. type I diabetes mellitus or uncontrolled type II diabetes mellitus

5. renal failure

6. liver disease

7. gastrointestinal disease that affected absorption