Memantine and Postoperative Pain

• Status: Terminated
• Trial end date: 2015-01-01
• Target enrollment: 0
• Participant gender: Male

Summary

Memantine is associated with improvement in pain relief after surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Memantine

Criteria

Inclusion Criteria:

• Male

• Age 18 to 75 years old

Exclusion Criteria:

• Chronic pain conditions or taking regular analgesics

• Taking psychotropic medications

• Parkinson's disease

• Narrow-angle glaucoma

• Known gastroduodenal ulcer

• History of seizure disorder

• Renal insufficiency, as defined by serum creatinine greater than 2 mg/dL

• Liver disease, including liver failure, cirrhosis, or acute hepatitis

• Significant coronary vascular disease or cardiac conduction system disease, as noted by ECG or history of cardiac symptoms, or cardiac ejection fraction less than 30%

• American Society of Anesthesiologists (ASA) score of 4 or higher

• Allergy to ketorolac or memantine