Memory Modulation by Pain During Anesthesia

• Status: Completed
• Trial end date: 2018-12-12
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pittsburgh
• Collaborator: Foundation for Anesthesia Education and Research
• Treatments: Dexmedetomidine; Ketamine; Midazolam

Criteria

Inclusion Criteria:

• Healthy adult volunteers, with normal memory and hearing, whose native language is English

Exclusion Criteria:

• pregnancy

• significant memory or hearing loss

• sleep apnea

• chronic pain

• metal or electronic implants

• claustrophobia

• Currently taking: antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, sleep-aids, or pain medication